反应详情

3-Phenyl-2-p-tolylpyrido[2,3-b]pyrazine (step 4) (179 mg, 0.602 mmol) under nitrogen in dry MeOH (5 ml) was treated with ammonium formate (190 mg, 3.01 mmol) and 10% palladium on carbon (64.1 mg, 0.060 mmol). The resulting mixture was heated at reflux for 16 hours. After cooling to RT, the mixture was filtered through Celite® (filter material) and the catalyst was washed with MeOH and MeOH/DCM (1:1). The filtrate was concentrated in vacuo and dissolved in DCM (50 ml). The solution was washed with water (×2) and brine (×1). The resulting organic portion was passed through a phase separating column and concentrated in vacuo to afford the title compound;

1. temperatureThe resulting mixture was heated
2. temperatureat reflux for 16 hours
3. filtrationthe mixture was filtered through Celite® (filter material)
4. washthe catalyst was washed with MeOH and MeOH/DCM (1:1)
5. concentrationThe filtrate was concentrated in vacuo
6. dissolutiondissolved in DCM (50 ml)
7. washThe solution was washed with water (×2) and brine (×1)
8. customseparating column
9. concentrationconcentrated in vacuo