Boronic Acid → 5-[(1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-carboxy-1-isopropenyl-5a,5b,8,8,11a-pentamethyl-1,2,3,4,5,6,7,7a,11,11b,12,13,13a,13b-tetradecahydrocyclopenta[a]chrysen-9-yl]thiophene-2-carboxylic acid

HRID 406878Notes

Reaction equation

C(CCC1C=CC([C:12]2[C:13]([CH3:43])([CH3:42])[C@H:14]3[C@:27]([CH3:30])([CH2:28][CH:29]=2)[C@@H:26]2[C@:17]([CH3:41])([C@@:18]4([CH3:40])[C@H:23]([CH2:24][CH2:25]2)[C@H:22]2[C@H:31]([C:34]([CH3:36])=[CH2:35])[CH2:32][CH2:33][C@:21]2([C:37]([OH:39])=[O:38])[CH2:20][CH2:19]4)[CH2:16][CH2:15]3)=CC=1)(O)=O.B([C:47]1[S:51][C:50]([C:52]([OH:54])=[O:53])=[CH:49][CH:48]=1)(O)O.B(O)O>>[C:37]([C@:21]12[CH2:33][CH2:32][C@@H:31]([C:34]([CH3:36])=[CH2:35])[C@@H:22]1[C@@H:23]1[C@@:18]([CH3:40])([CH2:19][CH2:20]2)[C@@:17]2([CH3:41])[C@@H:26]([C@:27]3([CH3:30])[C@@H:14]([CH2:15][CH2:16]2)[C:13]([CH3:42])([CH3:43])[C:12]([C:47]2[S:51][C:50]([C:52]([OH:54])=[O:53])=[CH:49][CH:48]=2)=[CH:29][CH2:28]3)[CH2:25][CH2:24]1)([OH:39])=[O:38]

Participants

Reactant 3

HCID 61668Boronic Acid

HCID 27798075-Boronothiophene-2-carboxylic acid

HCID 54761941(1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-9-[4-(2-carboxyethyl)phenyl]-1-isopropenyl-5a,5b,8,8,11a-pentamethyl-1,2,3,4,5,6,7,7a,11,11b,12,13,13a,13b-tetradecahydrocyclopenta[a]chrysene-3a-carboxylic acid

Product 1

HCID 547608835-[(1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-carboxy-1-isopropenyl-5a,5b,8,8,11a-pentamethyl-1,2,3,4,5,6,7,7a,11,11b,12,13,13a,13b-tetradecahydrocyclopenta[a]chrysen-9-yl]thiophene-2-carboxylic acid

Procedure

The title compound was prepared following the method described above for compound (1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-9-(4-(2-carboxyethyl)phenyl)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysene-3a-carboxylic acid (example 4a) using 5-boronothiophene-2-carboxylic acid as the reactant boronic acid. The product was isolated as a white solid (4.15 mg, 23%). LCMS: m/e 563.53 (M−H)−, 2.94 min (method 4). 1H NMR (400 MHz, <DMSOmix>) δ ppm 0.90 (br. s., 3H), 0.96 (s, 3H), 0.98 (s, 3H), 1.04 (s, 3H), 1.06 (s, 3H), 1.09-1.76 (m, 17H), 1.68 (s, 3H), 1.80-1.94 (m, 2H), 2.10-2.23 (m, 2H), 2.25-2.40 (m, 1H), 2.91-3.05 (m, 1H), 4.58 (br. s., 1H), 4.71 (br. s., 1H), 5.75 (d, J=5.86 Hz, 1H), 6.90 (d, J=3.22 Hz, 1H), 7.51 (br. s., 1H).

Sources & evidence

ORD record: ord-422808ffba004658aacc551c2c3cb62e
Source dataset: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08754068B2

Reaction notes

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