反应详情

2-Cloro-4-(3-fluoro-5-(piperazin-1-yl)phenyl)pyrimidine (0.29 g, 1 mmol) and ethyl aldehyde (0.13 g, 3 mmol) were mixed in dichloroethane (10 mL) and then added with NaBH(OAc)3 (0.64 g, 3 mmol). After stirring at room temperature under argon for overnight, the reaction mixture was quenched with saturated NaHCO3 and extracted with EtOAc. The organic layer was separated, dried with anhydrous MgSO4 and concentrated in vacuo to give desired product 2-Chloro-4-(3-(4-ethylpiperazin-1-yl)-5-fluorophenyl)pyrimidine.

1. customthe reaction mixture was quenched with saturated NaHCO3
2. extractionextracted with EtOAc
3. customThe organic layer was separated
4. dry with materialdried with anhydrous MgSO4
5. concentrationconcentrated in vacuo