反应详情

(S)-benzyl-1′-(5-ethylpyrimidin-2-yl)-2-oxo-[1,4′-bipiperidin]-3-ylcarbamate (2.176 g, 4.973 mmol) was dissolved in MeOH and 10% Pd/C (1 g) was added and stirred in a parr shaker at 30 psi overnight. The reaction was filtered through GF/F paper and separated on the reverse phase Horizon system to give (S)-3-amino-1′-(5-ethylpyrimidin-2-yl)-[1,4′-bipiperidin]-2-one (0.280 g, 0.9229 mmol, 18.56% yield) as a clear oil. Mass spectrum (apci) m/z=304.2 (M+H).

1. filtrationThe reaction was filtered through GF/F paper
2. customseparated on the reverse phase Horizon system