反应详情

To a solution of (S)-methyl 4-(1-(1-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperidin-4-yl)-2-oxopyrrolidin-3-yloxy)-3-fluorobenzoate (0.1 g, 0.19 mmol) in THF (2 mL) was added LiOH (3 M, 2 mL) and the reaction was stirred overnight at ambient temperature. The THF was removed with a stream of nitrogen. The aqueous layer was acidified with 1 N HCl to about pH 1 and the solid that formed was filtered and washed with water. The solid was dried under vacuum to yield (S)-4-(1-(1-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperidin-4-yl)-2-oxopyrrolidin-3-yloxy)-3-fluorobenzoic acid (0.040 g, 0.081 mmol, 42% yield).

1. customThe THF was removed with a stream of nitrogen
2. customthe solid that formed
3. filtrationwas filtered
4. washwashed with water
5. customThe solid was dried under vacuum