反应详情

To a solution of (S)-methyl 5-chloro-6-(4-(3-(2-fluoro-4-(methylsulfonyl)phenylamino)-2-oxopyrrolidin-1-yl)piperidin-1-yl)nicotinate (Example 156, Step A; 0.50 g, 0.95 mmol) in THF (20 mL) was added a 3 M solution of LiOH (3 mL) and the reaction was stirred overnight at ambient temperature. The THF was removed with a stream of nitrogen. The aqueous layer was acidified to pH 1 by the addition of 1 N HCl. The solids that formed were filtered, washed with water and dried under vacuum to give (S)-5-chloro-6-(4-(3-(2-fluoro-4-(methylsulfonyl)phenylamino)-2-oxopyrrolidin-1-yl)piperidin-1-yl)nicotinic acid (0.40 g, 82% yield).

1. customThe THF was removed with a stream of nitrogen
2. additionThe aqueous layer was acidified to pH 1 by the addition of 1 N HCl
3. customThe solids that formed
4. filtrationwere filtered
5. washwashed with water
6. customdried under vacuum