反应详情

tert-Butyl 4-((S)-3-(benzyloxycarbonylamino)-2-oxopyrrolidin-1-yl)-3,3-dimethylpiperidine-1-carboxylate (0.81 g, 1.8 mmol) was dissolved in methanol (20 mL) and the mixture was purged with N2 by three vacuum pump/N2 balloon cycles. 10% Palladium on carbon (dry basis, wet, Degussa type, 0.5 g) was added and the system was purged with 1 atm H2 by three vacuum pump/H2 balloon cycles. The reaction was stirred under the H2 atmosphere until the starting material was consumed. The mixture was filtered through Celite® and concentrated to afford tert-butyl 4-((S)-3-amino-2-oxopyrrolidin-1-yl)-3,3-dimethylpiperidine-1-carboxylate (0.59 g, 1.9 mmol, 100% yield) as a white solid.

1. customthe mixture was purged with N2 by three vacuum pump/N2 balloon cycles
2. addition10% Palladium on carbon (dry basis, wet, Degussa type, 0.5 g) was added
3. customthe system was purged with 1 atm H2 by three vacuum pump/H2 balloon cycles
4. customwas consumed
5. filtrationThe mixture was filtered through Celite®
6. concentrationconcentrated