反应详情

18.0 g (52.1 mmol) 4-[4-(1-Methoxycarbonyl-ethyl)-phenyl]-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester (VII.1) in 400 mL methanol are hydrogenated for 1 h at rt using 5.55 g (5.21 mmol) Pd/C. After that time, the catalyst is filtered off (celite) and the solvent is evaporated. The residue is purified by column chromatography (silica gel; heptane:EtOAc gradient 100:0->60:40).

1. filtrationAfter that time, the catalyst is filtered off (celite)
2. customthe solvent is evaporated
3. customThe residue is purified by column chromatography (silica gel; heptane:EtOAc gradient 100:0->60:40)