反应详情

温度

60 °C

A mixture of 2,2,2-trifluoro-1-[8-(methylamino)-3-azabicyclo[3.2.1]oct-3-yl]-1-ethanone (see step (v) above; 4.5 g, 16 mmol), benzylchloride (3.0 g, 16 mmol) and TEA (6.6 mL) in MeCN (50 mL) was stirred at 60° C. overnight. The mixture was evaporated and then DCM and water were added. The organic phase was washed with NaHCO3 solution, dried (Na2SO4) and then evaporated. The resulting crude product was purified by chromatography on silica gel (DCM eluant) to give 2.2 g (42%) of the sub-title compound.

1. customThe mixture was evaporated
2. additionDCM and water were added
3. washThe organic phase was washed with NaHCO3 solution
4. dry with materialdried (Na2SO4)
5. customevaporated
6. customThe resulting crude product was purified by chromatography on silica gel (DCM eluant)