反应详情

Example 29 (0.26 g, 0.83 mmol) and Pyr-HCl (5 g) were heated together at 210° C. for 30 minutes. The reaction was worked up by partitioning between EtOAc/MeOH and 2N HCl aq. The organic layer was washed with brine and dried over MgSO4. The organic layer was concentrated and the product triturated with MeOH to yield the desired pdt 31 as a tan solid (0.17 g): Mp>300° C.; 1H NMR (DMSO-d6) δ 12.49 (s, 1H), 11.09 (s, 1H), 8.22 (d, 1H, J=3.4 Hz), 8.20 (d, 1H, J=4.0 Hz), 7.76-7.61 (m, 2H), 6.61 (d, 1H, J=2.1 Hz), 6.31 (d, 1H, J=2.1 Hz); MS 283 (M−H)−.

1. customwere heated together at 210° C. for 30 minutes
2. customby partitioning between EtOAc/MeOH and 2N HCl aq. The organic layer
3. washwas washed with brine
4. dry with materialdried over MgSO4
5. concentrationThe organic layer was concentrated
6. customthe product triturated with MeOH