反应详情

The above mixture of tert-butyl 2-(6-(morpholine-4-carbonyl)-2-morpholino-4-oxo-4H-chromen-8-yl)-2,3-dihydro-1H-pyrrole-1-carboxylate compound and tert-butyl 2-(6-(morpholine-4-carbonyl)-2-morpholino-4-oxo-4H-chromen-8-yl)-2,5-dihydro-1H-pyrrole-1-carboxylate (1:1) (2.1 g, 2.05 mmol) and platinum(IV) oxide (0.093 g, 0.41 mmol) in ethanol (30 ml) was hydrogenated under 1.2 atm at room temperature for 4 h. The resulting solution was filtered and the filtrate was concentrated to dryness to afford the crude tert-butyl 2-(6-(morpholine-4-carbonyl)-2-morpholino-4-oxo-4H-chromen-8-yl)pyrrolidine-1-carboxylate (1.60 g, 76%) as an orange solid. Mass Spectrum: m/z [M+H]+=514.

1. filtrationThe resulting solution was filtered
2. concentrationthe filtrate was concentrated to dryness