反应详情

A mixture of 5-[4-[6-(4-n-hexylaminophenoxy)-1-methyl-1H-benzimidazol-2-ylmethoxy]benzyl]thiazolidine-2,4-dione (0.39 g), α,α,α-trifluoro-p-tolyl isocyanate (0.15 g) and anhydrous tetrahydrofuran (20 ml) was allowed to stand at room temperature for 2 days. The reaction mixture was concentrated and partitioned between ethyl acetate and water. The extract was dried over anhydrous sodium sulfate and then concentrated. The residue was reprecipitated from a mixture of ether and diisopropyl ether to afford the title compound (0.37 g, Rf=0.49: thin layer chromatography on a silica gel plate using ethyl acetate:n-hexane=2:1 as the eluant).

1. concentrationThe reaction mixture was concentrated
2. custompartitioned between ethyl acetate and water
3. dry with materialThe extract was dried over anhydrous sodium sulfate
4. concentrationconcentrated
5. customThe residue was reprecipitated from a mixture of ether and diisopropyl ether