反应详情

(R)-3-{4-[1-(4-Cyclohexylphenyl)-3-(3-methoxy-5-trifluoromethylphenyl)ureidomethyl]benzoyl-amino}-2-hydroxypropionic acid ethyl ester was dissolved in ethanol (15 mL) and sodium hydroxide (2 N, 2 mL) was added. The reaction mixture was stirred at room temperature for 60 min. Then ethanol was removed in vacuo, water (50 mL) was added and pH was adjusted with 4 N hydrochloric acid to acidic reaction. Filtration and washing with water (5×5 mL) and drying in vacuo afforded 460 mg of the title compound as a crystalline solid.

1. customThen ethanol was removed in vacuo, water (50 mL)
2. additionwas added
3. custompH was adjusted with 4 N hydrochloric acid to acidic reaction
4. filtrationFiltration
5. washwashing with water (5×5 mL)
6. customdrying in vacuo