反应详情

To a solution of N,N′-di-tert-butoxycarbonyl-7-[1-(2-hydroxyethyl)-piperidin-4-ylmethoxy]-1,2,3,4-tetrahydroisoquinoline-2-carboxamidine (60 mg) in chloroform (0.6 ml)solution was added trifluoroacetic acid (0.3 ml), and the mixture was stirred at room temperature for 5 hours. After completion of the reaction, the solvent was evaporated and to the obtained residue was added a hydrogen chloride—ethanol solution and insoluble material was removed. The resultant mixture was concentrated and dried under reduced pressure to give the title compound (40 mg).

1. customAfter completion of the reaction
2. customthe solvent was evaporated and to the obtained residue
3. additionwas added a hydrogen chloride—ethanol solution and insoluble material
4. customwas removed
5. concentrationThe resultant mixture was concentrated
6. customdried under reduced pressure