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HRID413874

反应详情

EQUATION

反应方程式

HRID 413874 的结构方程式

REACTANTS

反应物

2
结构：CC(C)(C)OC(=O)NC(CC(F)(F)F)C(=O)O
HCID12098057

未命名化合物

结构：C[C@H](N)C(=O)[C@H]1C(=O)N(C)C(N)CC2=C1C=CCC2.Cl
HCID69736556

未命名化合物

PRODUCTS

生成物

1
结构：C[C@H](NC(=O)C(N)CC(F)(F)F)C(=O)[C@H]1C(=O)N(C)C(N)CC2=C1C=CCC2
HCID86592604

未命名化合物

PROCEDURE

实验过程

Following General Procedure D above using 1-(S)-[L-alaninyl]-amino-3-methyl-4,5,6,7-tetrahydro-2H-3-benzazepin-2-one hydrochloride (Example 7-30, below) and 2-(N-Boc-amino)-4,4,4-trifluorobutyric acid (Oakwood), the protected intermediate was prepared. The Boc-group was removed using 5.0 M HCl in dioxane and the resulting free-base purified by flash chromatography CHCl3/MeOH (97.3) yielding the title compounds.

WORKUP

后处理

  1. customthe protected intermediate was prepared
  2. customThe Boc-group was removed
  3. customthe resulting free-base purified by flash chromatography CHCl3/MeOH (97.3)