2-Phthalimidoethanesulfonyl chloride → 2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-ethanesulfonic acid (1-cyclopropyl-piperidin-4-yl)-amide

HRID 416492Notes

Reaction equation

HRID 416492 reaction equation
[CH:1]1([N:4]2[CH2:9][CH2:8][CH:7]([NH2:10])[CH2:6][CH2:5]2)[CH2:3][CH2:2]1.[O:11]=[C:12]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[C:14](=[O:21])[N:13]1[CH2:22][CH2:23][S:24](Cl)(=[O:26])=[O:25]>>[CH:1]1([N:4]2[CH2:9][CH2:8][CH:7]([NH:10][S:24]([CH2:23][CH2:22][N:13]3[C:12](=[O:11])[C:20]4[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=4)[C:14]3=[O:21])(=[O:25])=[O:26])[CH2:6][CH2:5]2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 3087392-Phthalimidoethanesulfonyl chlorideHCID 162276441-Cyclopropylpiperidin-4-amine

Product 1

HCID 666248122-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-ethanesulfonic acid (1-cyclopropyl-piperidin-4-yl)-amide

Procedure

2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-ethanesulfonic acid (1-cyclopropyl-piperidin-4-yl)-amide was prepared by an analogous procedure as described for example 1 i) starting from 154 mg (1.1 mmol) 1-cyclopropyl-piperidin-4-ylamine (obtainable as described in EP 1479676) and 300 mg (1 equiv.) 2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethanesulfonyl chloride. The product was obtained in crude form as a colorless foam.

Workup

  1. customThe product was obtained in crude form as a colorless foam

Sources & evidence

ORD record
ord-594ce6ee71034727b37d316a9159f79a
Source dataset
uspto-grants-2012_01
Patent number
US08088925B2

Reaction notes

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