反应详情

5-Chloro-pyridine-2-carboxylic acid[2-(1-isopropyl-piperidin-4-ylsulfamoyl)-ethyl]-amide was prepared by an analogous procedure as described in example 9 starting from 104 mg (1.1 equiv.) 5-chloro-pyridine-2-carboxylic acid and 150 mg (0.60 mmol) 2-amino-ethanesulfonic acid (1-isopropyl-piperidin-4-yl)-amide. Final purification by preparative RP-HPLC (CH3CN/H2O gradient+0.1% TFA) gave pure 5-chloro-pyridine-2-carboxylic acid [2-(1-isopropyl-piperidin-4-ylsulfamo-yl)-ethyl]-amide. The title compound was obtained as its trifluoroacetate in form of a colorless amorphous material. Yield: 60 mg MS (ES+): m/e=389, chloro pattern.

1. customFinal purification by preparative RP-HPLC (CH3CN/H2O gradient+0.1% TFA)