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HRID416541

反应详情

EQUATION

反应方程式

HRID 416541 的结构方程式

REACTANTS

反应物

2
结构：ClCc1nnc(C2CC2)s1
HCID2757679

2-(Chloromethyl)-5-cyclopropyl-1,3,4-thiadiazole

C6H7ClN2S

结构：CC(C)N1CCC(NS(=O)(=O)CCNC(=O)c2ccc(Cl)s2)CC1
HCID11990478

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)N1CCC(N(Cc2nnc(C3CC3)s2)S(=O)(=O)CCNC(=O)c2ccc(Cl)s2)CC1
HCID66624803

未命名化合物

PROCEDURE

实验过程

5-Chloro-thiophene-2-carboxylic acid {2-[(5-cyclopropyl-[1,3,4]thiadiazol-2-ylmethyl)-(1-isopropyl-piperidin-4-yl)-sulfamoyl]-ethyl}-amide was prepared by an analogous procedure as described in example 15 starting from 89 mg (2 equiv.) 2-chloromethyl-5-cyclopropyl-[1,3,4]thiadiazole and 100 mg (0.25 mmol) 5-chloro-thiophene-2-carboxylic acid [2-(1-isopropyl-piperidin-4-ylsulfamoyl)-ethyl]-amide. Final purification by preparative RP-HPLC (CH3CN/H2O gradient+0.1% TFA) gave pure 5-chloro-thiophene-2-carboxylic acid {2-[(5-cyclopropyl-[1,3,4]thiadiazol-2-ylmethyl)-(1-isopropyl-piperidin-4-yl)-sulfamoyl]-ethyl}-amide. The title compound was obtained as its trifluoroacetate in form of a colorless amorphous material.

WORKUP

后处理

  1. custom5-Chloro-thiophene-2-carboxylic acid {2-[(5-cyclopropyl-[1,3,4]thiadiazol-2-ylmethyl)-(1-isopropyl-piperidin-4-yl)-sulfamoyl]-ethyl}-amide was prepared by an analogous procedure
  2. customFinal purification by preparative RP-HPLC (CH3CN/H2O gradient+0.1% TFA)