反应详情

This was prepared from [4-(6-bromo-7-piperazin-1-yl-3H-imidazo[4,5-b]pyridin-2-yl)-phenyl]-dimethyl-amine (20 mg, 0.050 mmol), using CHCl3 (1.5 mL) and ethyl isocyanate (1.1 eq, 0.055 mmol, 43 μL). Filtration of the precipitate after 16 h gave the product (13 mg, 56%) as a pale yellow solid; 1H-NMR (500 MHz, DMSO-d6) 1.05 (t, J=7.1 Hz, 3H, CH2CH3), 3.00 (s, 6H, N(CH3)2), 3.09 (qd, J=7.1, 5.4 Hz, 2H, NHCH2), 3.50-3.52 (m, 4H, piperazine N(CH2)2), 3.55-3.57 (4H, m, piperazine N(CH2)2), 6.55 (t, J=5.4 Hz, 1H, NHCH2), 6.82 (d, J=9.0 Hz, 2H, N,N-dimethylaminophenyl), 8.01 (d, J=9.0 Hz, 2H, N,N-dimethylaminophenyl), 8.17 (s, 1H, imidazo[4,5-b]pyridine H-5), 13.18 (s, br, 1H, imidazo[4,5-b]pyridine NH);

1. filtrationFiltration of the precipitate after 16 h