反应详情

The a solution of 4-[3-[6-(3-Bromo-5-methanesulfonyloxymethyl-phenoxy)-hexyl]-2-(2-ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester (2.5 g, 3.72 mmol) in MeCN (40 mL), N,N-dimethylamine 2M/THF (3.72 mL, 7.44 mmol) was added, and stirred at room temperature overnight. The solvent was removed under reduced pressure. Flash column chromatography (50% EtOAc/Hex) provided a light yellow oil (1.47 g, 64% yield). 1H NMR (CDCl3): δ 7.08 (t, 1H), 7.03 (s, 1H), 6.93 (s, 1H), 6.79 (s, 1H), 6.77 (d, 1H), 6.68 (d, 1H), 4.17-4.06 (m, 4H), 3.99 (dd, 2H), 3.92 (dd, 2H), 3.34 (s, 2H), 2.97 (dd, 2H), 2.63 (dd, 2H), 2.56-2.46 (m, 4H), 2.23 (s, 6H), 2.17-0.89 (m, 16H).

1. customThe solvent was removed under reduced pressure