HRID417040

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCOC(=O)CCCOc1cccc(CCCCCCOc2cc(C(C)=O)cc(-c3ccsc3)c2)c1CCC(=O)OCC

HCID59496815

未命名化合物

PRODUCTS

生成物

结构：CC(=O)c1cc(OCCCCCCc2cccc(OCCCC(=O)O)c2CCC(=O)O)cc(-c2ccsc2)c1

HCID46929166

未命名化合物

收率 67%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID14798

Sodium Hydroxide

HNaO

PROCEDURE

实验过程

A similar procedure as described in Example 43, step 5 was used, starting from 4-[3-[6-(3-acetyl-5-thiophen-3-yl-phenoxy)-hexyl]-2-(2-ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester (272 mg, 0.44 mmol) and 1.0 N aqueous sodium hydroxide (10 mL) to afford 4-[3-[6-(3-acetyl-5-thiophen-3-yl-phenoxy)-hexyl]-2-(2-carboxy-ethyl)-phenoxy]-butyric acid (163 mg, 66%) as a light brown solid: ES(+)-HRMS m/e calcd for C31H36O7S (M+Na)+ 575.2074. found 575.2074.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0d9919ed985f4e809c2eddc506c1e58e
来源数据集: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08088936B2
来源说明: uspto-grants-2012_01

反应 SMILES

C([O:3][C:4](=[O:43])[CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][O:21][C:22]2[CH:27]=[C:26]([C:28]3[CH:32]=[CH:31][S:30][CH:29]=3)[CH:25]=[C:24]([C:33](=[O:35])[CH3:34])[CH:23]=2)[C:10]=1[CH2:36][CH2:37][C:38]([O:40]CC)=[O:39])C>[OH-].[Na+]>[C:33]([C:24]1[CH:23]=[C:22]([CH:27]=[C:26]([C:28]2[CH:32]=[CH:31][S:30][CH:29]=2)[CH:25]=1)[O:21][CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][C:11]1[C:10]([CH2:36][CH2:37][C:38]([OH:40])=[O:39])=[C:9]([CH:14]=[CH:13][CH:12]=1)[O:8][CH2:7][CH2:6][CH2:5][C:4]([OH:43])=[O:3])(=[O:35])[CH3:34]