Sulfuric Acid → [3-Benzo[1,3]dioxol-5-yl-5-(4-methoxy-benzyloxy)-phenyl]-cyclopropyl-methanone

HRID 417052Notes

Reaction equation

HRID 417052 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[CH:11]=[C:12]([CH:15]=[C:16]([O:18][CH2:19][C:20]4[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=4)[CH:17]=3)[C:13]#N)=[CH:9][C:4]=2[O:3][CH2:2]1.[CH:28]1([Mg]Cl)[CH2:30][CH2:29]1.S(=O)(=O)(O)[OH:34]>C1COCC1.C(OCC)C>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[CH:11]=[C:12]([C:13]([CH:28]4[CH2:30][CH2:29]4)=[O:34])[CH:15]=[C:16]([O:18][CH2:19][C:20]4[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=4)[CH:17]=3)=[CH:9][C:4]=2[O:3][CH2:2]1

Participants

6

Reactant 3

HCID 1118Sulfuric AcidHCID 594968393-Benzo[1,3]dioxol-5-yl-5-(4-methoxy-benzyloxy)-benzonitrileHCID 178478986HCID 178478986, compound

Product 1

HCID 59496824[3-Benzo[1,3]dioxol-5-yl-5-(4-methoxy-benzyloxy)-phenyl]-cyclopropyl-methanoneYield 91%

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 3-benzo[1,3]dioxol-5-yl-5-(4-methoxy-benzyloxy)-benzonitrile (250 mg) in anhydrous THF (3 mL) were added a solution of cyclopropylmagnesium chloride (4.1 mL of 0.5 M solution in THF) and catalytic amount of cuprous bromide (2 mg). The resulting reaction mixture was refluxed for 1.5 h. After it was cooled down, 10% sulfuric acid (1.5 mL) was added and stirring was continued for 30 min at room temperature. Then the reaction mixture was diluted with diethyl ether, washed with water and brine. The organic extract was dried over anhydrous sodium sulfate, concentrated and purified on a silica gel column using ethyl acetate and hexanes to yield 253 mg of the title compound (91% yield). HRMS calcd for C25H22O5 [M+H]+ 403.1540, observed 403.1537.

Workup

  1. customThe resulting reaction mixture
  2. temperaturewas refluxed for 1.5 h
  3. temperatureAfter it was cooled down
  4. washwashed with water and brine
  5. extractionThe organic extract
  6. dry with materialwas dried over anhydrous sodium sulfate
  7. concentrationconcentrated
  8. custompurified on a silica gel column

Sources & evidence

ORD record
ord-6af74d6d86da436ba62451dce57942bd
Source dataset
uspto-grants-2012_01
Patent number
US08088936B2

Reaction notes

Loading…