反应详情

The solution of 0.55 g (1.45 mmol) 2-(6-benzyloxy-pyridin-3-yloxy)-4-bromo-butyric acid methyl ester in 8 mL tetrahydrofuran was cooled to 0° C. and 0.17 g (1.5 mmol) potassium tert-butoxide were added. The resulting pale yellow solution was stirred for 3 h at room temperature and then poured onto water. The aqueous phase was extracted three times with ethyl acetate and the organic layers were washed with brine, dried over magnesium sulfate, filtered and evaporated to give the product as a colorless oil (92%) which was pure enough for the next step. MS (Turbo Spray): m/z=210.1 [M+H].

1. additionpoured onto water
2. extractionThe aqueous phase was extracted three times with ethyl acetate
3. washthe organic layers were washed with brine
4. dry with materialdried over magnesium sulfate
5. filtrationfiltered
6. customevaporated