反应详情

The title compound was prepared in analogy to Example 4, intermediate, from 2-[2-(4-chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-2-cyclohexyl-ethanol (Example 1, intermediate c), methyl 5-bromo-6-hydroxynicotinate (commercially available), triphenylphosphine and di-tert-butyl azodicarboxylate. The residue obtained after work-up was crystallized from acetonitrile. Colorless solid (86%). MS (Turbo Spray): m/z=604.3 [M+H].

1. customThe residue obtained after work-up
2. customwas crystallized from acetonitrile