反应详情

28 g (0.067 mol) of 5,11-dihydro-11-[1-oxo-2-methyl-6-(4-methyl-1-piperazinyl)-4-hexynyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one are suspended in 350 ml of absolute ethanol and 45 ml of ethereal hydrochloric acid are added with stirring at boiling temperature. A clear solution is obtained at first, which goes cloudy again after some time. A fine crystal slurry is precipitated which is cooled and suction filtered and then washed with 50 ml of absolute ethanol and 150 ml of acetone.

1. customA clear solution is obtained at first, which
2. customA fine crystal slurry is precipitated which
3. temperatureis cooled
4. filtrationsuction filtered
5. washwashed with 50 ml of absolute ethanol and 150 ml of acetone