反应详情

The compound was synthesized starting from 1-(1H-benzo[d]imidazol-5-yl)-5-(4-(4-oxocyclohexyl)phenyl)pyrrolidine-2,4-dione (1.5 g, 3.87 mmol) and thionyl chloride (1.1 g, 9.1 mmol) according to method 6 described above. The compound was further treated with TFA (5 ml) at room temperature for 1 h. The volatiles were evaporated and the residue was partitioned between sodium bicarbonate solution and MeOH/CHCl3 (5/95). The organic layer was washed with brine, dried over Na2SO4 and evaporated. The residue was purified by column chromatography to give the title compound.

1. customThe compound was synthesized
2. customThe volatiles were evaporated
3. customthe residue was partitioned between sodium bicarbonate solution and MeOH/CHCl3 (5/95)
4. washThe organic layer was washed with brine
5. dry with materialdried over Na2SO4
6. customevaporated
7. customThe residue was purified by column chromatography