HRID418101

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11430

Potassium Carbonate

CK2O3

结构：CCOC(=O)CCCOc1cccc(CCCCCCBr)c1CCC(=O)OCC

HCID57586491

未命名化合物

HCID57863088

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)CCCOc1cccc(CCCCCCOc2cc(Br)cc(S(=O)(=O)CC)c2)c1CCC(=O)OCC

HCID57863128

未命名化合物

收率 95%

PROCEDURE

实验过程

A similar procedure as described in Example 40, step 6 was used, starting from 4-[3-(6-bromo-hexyl)-2-(2-ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester (1.13 g, 2.39 mmol), 3-bromo-5-ethanesulfonyl-phenol (576 mg, 2.17 mmol), and potassium carbonate (600 mg, 4.34 mmol) to afford 4-[3-[6-(3-bromo-5-ethanesulfonyl-phenoxy)-hexyl]-2-(2-ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester (1.35 g, 95%) as a colorless viscous oil: ES(+)-HRMS m/e calcd for C31H43BrO8S (M+Na)+ 677.1754, found 677.1756.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1f463ab4e13b409084a6741bca9fd496
来源数据集: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08093253B2
来源说明: uspto-grants-2012_01

反应 SMILES

[CH2:1]([O:3][C:4](=[O:29])[CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20]Br)[C:10]=1[CH2:22][CH2:23][C:24]([O:26][CH2:27][CH3:28])=[O:25])[CH3:2].[Br:30][C:31]1[CH:32]=[C:33]([OH:42])[CH:34]=[C:35]([S:37]([CH2:40][CH3:41])(=[O:39])=[O:38])[CH:36]=1.C(=O)([O-])[O-].[K+].[K+]>>[CH2:1]([O:3][C:4](=[O:29])[CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][O:42][C:33]2[CH:34]=[C:35]([S:37]([CH2:40][CH3:41])(=[O:39])=[O:38])[CH:36]=[C:31]([Br:30])[CH:32]=2)[C:10]=1[CH2:22][CH2:23][C:24]([O:26][CH2:27][CH3:28])=[O:25])[CH3:2]