5'-((1H-1,2,4-triazol-1-yl)methyl)-2'-cyanobiphenyl-4-yl dimethylsulfamate → 3-Chloro-2'-Cyano-5'-(1h-1,2,4-Triazol-1-Ylmethyl)biphenyl-4-Yl Sulfamate

HRID 418419Notes

Reaction equation

HRID 418419 reaction equation
C[N:2](C)[S:3](=[O:27])(=[O:26])[O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[C:15]([CH2:17][N:18]3[CH:22]=[N:21][CH:20]=[N:19]3)[CH:14]=[CH:13][C:12]=2[C:23]#[N:24])=[CH:7][C:6]=1[Cl:25].CN(C)S(=O)(=O)OC1C=CC(C2C=C(CN3C=NC=N3)C=CC=2C#N)=CC=1>>[S:3](=[O:26])(=[O:27])([O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[C:15]([CH2:17][N:18]3[CH:22]=[N:21][CH:20]=[N:19]3)[CH:14]=[CH:13][C:12]=2[C:23]#[N:24])=[CH:7][C:6]=1[Cl:25])[NH2:2]

Participants

3

Reactant 2

HCID 451409545'-((1H-1,2,4-triazol-1-yl)methyl)-2'-cyanobiphenyl-4-yl dimethylsulfamateHCID 451411525'-((1H-1,2,4-triazol-1-yl)methyl)-3-chloro-2'-cyanobiphenyl-4-yl dimethylsulfamate

Product 1

HCID 445210663-Chloro-2'-Cyano-5'-(1h-1,2,4-Triazol-1-Ylmethyl)biphenyl-4-Yl Sulfamate

Procedure

5′-((1H-1,2,4-triazol-1-yl)methyl)-3-chloro-2′-cyanobiphenyl-4-yl dimethylsulfamate 24, The title compound was prepared from 22 using similar conditions to those described for the synthesis of 21. Chromatography (CH2Cl2/acetone 75:25) eluted 24 as a white solid (0.189 g, 60%), mp 119-120° C.; 1H NMR δH (270 MHz, CDCl3) 3.07 (s, 6H), 5.45 (s, 2H), 7.30-7.33 (m, 2H), 7.43 (dd, J=2.2 Hz, 8.4 Hz, 1H), 7.58 (d, J=2.2 Hz, 1H), 7.62 (d, J=10.9 Hz, 1H), 7.77 (d, J=8.7 Hz, 1H), 8.01 (s, 1H) and 8.18 (s, 1H); LCMS (APCI), m/z 418 (40, [37CIM+H]−), 416 (100, [35CIM−-H]−); HRMS (ES+) m/z calcd. for C18H17ClN5O3S [M+H]+: 418.0735, found 418.0725; Anal. (C18H16ClN5O3S) C, H, N.

Workup

  1. washChromatography (CH2Cl2/acetone 75:25) eluted 24 as a white solid (0.189 g, 60%), mp 119-120° C.

Sources & evidence

ORD record
ord-13baeb0a37764a20886bac7be345f8e0
Source dataset
uspto-grants-2012_01
Patent number
US08093279B2

Reaction notes

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