反应详情

温度

50 °C

To a mixture of N-[2-(6-azido-pyridine-2-carbonyl)-5-chloro-pyridin-3-yl]-4-tert-butyl-N-methoxymethyl-benzenesulfonamide (0.3 mmol, 155 mg) in THF (3 mL) was added 3-[bis-(2-carboxy-ethyl)-phosphanyl]-propionic acid (1 mmol, 250 mg). The mixture was stirred at 50° C. for 3 h. Upon completion of the reduction, the THF was removed under reduced pressure. The residue was diluted with EtOAc and the organics were washed with saturated sodium bicarbonate, dried with sodium sulfate, concentrated in vacuo, and purified via automated silica gel chromatography to generate the desired product. MS m/z: 489.1 (M+H)+.

1. customUpon completion of the reduction, the THF was removed under reduced pressure
2. additionThe residue was diluted with EtOAc
3. washthe organics were washed with saturated sodium bicarbonate
4. dry with materialdried with sodium sulfate
5. concentrationconcentrated in vacuo
6. custompurified