反应详情

温度

65 °C

A 2-necked 2-liter round bottom flask was charged with 2-{[7-(benzyloxy)-3-nitroquinolin-4-yl]amino}ethanol (95.0 g, 0.28 mol) and pyridine (400 mL). The suspension was heated to 65° C. To the resulting homogenous solution was added in one portion tert-butyldimethylsilyl chloride (46.4 g, 0.31 mol, 1.1 eq) and 4-(N,N-dimethylamino)pyridine (3.42 g, 0.028 mol, 0.1 eq). The reaction temperature rose to 87° C., was slowly cooled to 65° C., and was maintained overnight at this temperature. The reaction was determined to be incomplete. Additional tert-butyldimethylsilyl chloride (20 g, 0.13 mol, 0.5 eq) was added in one portion and the reaction temperature was increased to 70° C. for 8 hours. The reaction was still not complete. Additional tert-butyldimethylsilyl chloride (21.5 g, 0.14 mol, 0.5 eq) was added in one portion and the reaction was maintained at 70° C. overnight. The reaction was now complete. The reaction mixture was poured into a 2-liter flask, followed by an ethyl acetate rinse, and set aside over the weekend. A precipitate, determined to be pyridine hydrochloride, formed and was removed by filtration. The reaction mixture was then concentrated under reduced pressure to a brown/yellow solid. The solid was slurried in ethyl acetate and collected by filtration; this was repeated three times. The combined filtrates were washed with water and then concentrated to approximately one-third of the original volume until solid began to precipitate. The mixture was diluted with hexane (700 mL) and stirred for an additional hour. A light brown solid was collected by vacuum filtration and dried overnight to provide 102.6 g of 7-(benzyloxy)-N-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)-3-nitroquinolin-4-amine, which was used without further purification in the next step.

1. customrose to 87° C.
2. temperaturewas slowly cooled to 65° C.
3. temperaturewas maintained overnight at this temperature
4. temperaturethe reaction temperature was increased to 70° C. for 8 hours
5. temperaturethe reaction was maintained at 70° C. overnight
6. additionThe reaction mixture was poured into a 2-liter flask
7. washrinse
8. customformed
9. customwas removed by filtration
10. concentrationThe reaction mixture was then concentrated under reduced pressure to a brown/yellow solid
11. filtrationcollected by filtration
12. washThe combined filtrates were washed with water
13. concentrationconcentrated to approximately one-third of the original volume until solid
14. customto precipitate
15. additionThe mixture was diluted with hexane (700 mL)
16. filtrationA light brown solid was collected by vacuum filtration
17. customdried overnight