反应详情

3′-Isopropoxy-4′-methoxyacetophenone (8) (150 mg, 0.720 mmol) was condensed with compound 19 (162 mg, 0.792 mmol) according to the general procedure II-A defined above. After being heated for 3 h the reaction mixture was cooled and the solvent removed under reduced pressure. The ensuing yellow oil was dissolved in CH2Cl2 (20 mL) and the resulting solution washed with H2O (2×15 mL) then dried (MgSO4), filtered and concentrated under reduced pressure. The oil thus obtained was subjected to flash chromatography (15:85 v/v ethyl acetate/hexane elution) to afford the title compound CP30254 (229 mg, 89%) as a pale-yellow oil, which solidified upon extensive standing, m.p. 44.5-46.1° C., Rf 0.5 in 1:1 v/v ethyl acetate/hexane.

1. temperatureAfter being heated for 3 h the reaction mixture
2. temperaturewas cooled
3. customthe solvent removed under reduced pressure
4. dissolutionThe ensuing yellow oil was dissolved in CH2Cl2 (20 mL)
5. washthe resulting solution washed with H2O (2×15 mL)
6. dry with materialthen dried (MgSO4)
7. filtrationfiltered
8. concentrationconcentrated under reduced pressure
9. customThe oil thus obtained
10. washwas subjected to flash chromatography (15:85 v/v ethyl acetate/hexane elution)