反应详情

4′-Hydroxy-3′-methoxyacetophenone (25) (150 mg, 0.903 mmol) was condensed with compound 19 (0.203 g, 0.992 mmol) according to the general procedure II-A defined above. After being heated for 3 h the reaction mixture was cooled and the solvent removed under reduced pressure. The ensuing residue was dissolved in CH2Cl2 (20 mL), washed with H2O (2×15 mL) then dried (MgSO4), filtered and concentrated under reduced pressure. The residue thus obtained was subjected to flash chromatography (1:9 v/v ethyl acetate/hexane elution) to afford the title compound CP30261 (158 mg, 55%) as a yellow solid, m.p. 118.4-121.1° C., Rf 0.5 in 1:1 v/v ethyl acetate/hexane.

1. temperatureAfter being heated for 3 h the reaction mixture
2. temperaturewas cooled
3. customthe solvent removed under reduced pressure
4. dissolutionThe ensuing residue was dissolved in CH2Cl2 (20 mL)
5. washwashed with H2O (2×15 mL)
6. dry with materialthen dried (MgSO4)
7. filtrationfiltered
8. concentrationconcentrated under reduced pressure
9. customThe residue thus obtained
10. washwas subjected to flash chromatography (1:9 v/v ethyl acetate/hexane elution)