反应详情

The title compound (0.092 g, 0.12 mmol, 51%) was prepared from 5-[3-(2-chloro-4-pyrimidinyl)imidazo[1,2-a]pyridin-2-yl]-N-(2,6-difluorophenyl)-2-[(1-methylethyl)oxy]benzamide (Intermediate Example 7) and 2-(methyloxy)-4-[2-(4-methyl-1-piperazinyl)ethyl]aniline (Example 131, step D) in an analogous manner to that described for Example 26, step E. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.39 (d, J=5.9 Hz, 6H), 2.13 (s, 3H), 2.26-2.35 (m, 3H), 2.38-2.45 (m, 3H), 2.52 (d, J=8.8 Hz, 4H), 2.66-2.75 (m, 2H), 3.82 (s, 3H), 4.82-4.91 (m, 1H), 6.63 (d, J=5.1 Hz, 1H), 6.76 (dd, J=8.3, 1.7 Hz, 1H), 6.92-7.03 (m, 2H), 7.19 (t, J=7.9 Hz, 2H), 7.30 (d, J=8.8 Hz, 1H), 7.34-7.40 (m, 1H), 7.44 (dd, J=8.4, 6.2 Hz, 1H), 7.64 (d, J=8.1 Hz, 1H), 7.67-7.77 (m, 2H), 8.07 (d, J=2.2 Hz, 1H), 8.27 (d, J=5.1 Hz, 1H), 8.49 (s, 1H), 9.36 (d, J=6.2 Hz, 1H), 9.70 (s, 1H). MS (M+H, ES+) 733.