反应详情

The title compound was prepared in analogous manner as described for example 1c from (4-bromomethyl-2-fluoro-phenyl)-carbamic acid benzyl ester (37 g, 109 mmol) and 5-tert-butoxycarbonylamino-4-oxo-tetrahydro-thiopyran-3-carboxylic acid allyl ester (33 g, 105 mmol, example 1b) to yield a diastereomeric mixture of a yellow solid: TLC (cyclohexane-EtOAc 1:1) Rf=0.77; ESIMS [M+NH4]+=590; LCMS [M+NH4]+=590, RtI=1.60 min.

1. customto yield
2. additiona diastereomeric mixture of a yellow solid
3. customLCMS [M+NH4]+=590, RtI=1.60 min.