反应详情

The title compound was prepared in analogous manner as described for example 24j) from (3R,4S,5S)-3-(3-tert-butyl-benzylamino)-5-(3,5-difluoro-4-nitro-benzyl)-1,1-dioxo-hexahydro-1lambda*6*-thiopyran-4-ol (example 24i) and (R)-1,1,1-trifluoro-3-methoxy-propan-2-ol to yield the title compound as a colorless foam: TLC (EtOAc-MeOH 19:1) Rf=0.47; HPLC RtA=2.13 min; ESIMS [M+H]+=607; 1H NMR (600 MHz, DMSO-d6): δ 7.34 (s, 1H), 7.28 (s, 1H), 7.24 (m, 2H), 7.143 (d, 1H), 7.10 (d, 1H), 5.59 (m, 1H), 5.30 (d, 1H), 3.80 (m, 2H), 3.70 (dd, 1H), 3.64 (d, 1H), 3.40 (dt, 1H), 3.29 (s, 3H), 3.21 (m, 1H), 3.12 (dd, 1H), 3.03 (m, 2H), 2.81 (m, 1H), 2.62 (dd, 1H), 2.42 (m, 1H), 2.14 (m, 1H), 1.27 (s, 9H).

1. customThe title compound was prepared in analogous manner