反应详情

0.32 g (2.1 mmoles) of 3,5-dimethoxyaniline, 0.26 g (1.0 mmol) of 2-bromo-1-(3,5-dimethoxyphenyl)ethanone and 0.42 ml (3.3 mmol) of N,N-dimethylaniline were placed in a vial. The vial was placed inside a monomode microwave reactor and was radiated at a power of 100 W, at a temperature of 150° C. for 10 minutes. After cooling the reaction vial, the mixture was dissolved in AcOEt, was washed with an aqueous HCl 2N solution, was dried on anhydrous Na2SO4 and was evaporated at low pressure. The crude portion was purified by means of pressure column chromatography (Eluent: AcOEt/hexanes) obtaining 4,6-dimethoxy-2-(3,5-dimethoxyphenyl)-1H-indole.

1. customThe vial was placed inside a monomode microwave reactor
2. temperatureAfter cooling the reaction vial, the mixture
3. washwas washed with an aqueous HCl 2N solution
4. dry with materialwas dried on anhydrous Na2SO4
5. customwas evaporated at low pressure
6. customThe crude portion was purified by means of pressure column chromatography (Eluent: AcOEt/hexanes)