反应详情

A 1.81 ml portion of methanesulfonic acid was added to a methanol solution (10 ml) of 1.0 g N-(4-{[2-(pyridin-3-yl)piperidin-1-yl]sulfonyl}phenyl)acetamide and stirred overnight at room temperature. The reaction liquid was poured into ice water and neutralized with sodium bicarbonate, and then layer separation operation was carried out by adding ethyl acetate. The organic layer was washed with saturated sodium chloride aqueous solution, dried with anhydrous sodium sulfate and then concentrated under a reduced pressure to obtain 695 mg of 4-{[2-(pyridin-3-yl)piperidin-1-yl]sulfonyl}aniline as pale yellow crystals.

1. customThe reaction liquid
2. customlayer separation operation
3. additionby adding ethyl acetate
4. washThe organic layer was washed with saturated sodium chloride aqueous solution
5. dry with materialdried with anhydrous sodium sulfate
6. concentrationconcentrated under a reduced pressure