反应详情

To methyl 1-(2-tert-butoxy-2-oxo ethyl)-3-cyclo hexyl-2-phenyl-1H-indole-6-carboxylate in DCM/H2O (2:1; 0.15 M), TFA (>300 eq) were added at RT and the reaction left stirring for 1 h. The volatiles were removed in vacuo, and the residue diluted with DCM. The organic phase was washed with brine, dried over Na2SO4, filtered and the solvent evaporated in vacuo to afford the title compound (98%). (ES+) m/z 392 (M+H)+

1. waitthe reaction left
2. customThe volatiles were removed in vacuo
3. additionthe residue diluted with DCM
4. washThe organic phase was washed with brine
5. dry with materialdried over Na2SO4
6. filtrationfiltered
7. customthe solvent evaporated in vacuo