反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
PROCEDURE
实验过程
A solution of 4-(4-methyl-piperazin-1-ylmethyl)-N-[3-(2-oxo-2,3-dihydro-1H-indol-7-ylamino)-phenyl]-benzamide (23 mg, 0.05 mmol) is heated with 1H-pyrrole-2-carbaldehyde (5 mg, 0.05 mmol) in ethanol (2 ml) in the presence of 2 drops of piperidine for 12 hours. It is then concentrated and purified by HPLC to give the desired compound: 1H NMR (DMSO-d6) δ 2.40-2.48 (m, 2H), 2.79 (s, 3H), 2.96-3.08 (m, 4H), 3.36-3.46 (m, 2H), 3.75 (s, 2H), 6.37 (s, 1H), 6.71 (d, 1H, J=7.8 Hz), 6.85 (s, 1H), 6.97 (t, 1H, J=7.8 Hz), 7.11 (d, 1H, J=7.2 Hz), 7.19 (t, 1H, J=7.8 Hz), 7.24 (d, 1H, J=7.8 Hz), 7.30 (t, 1H, J=7.8 Hz), 7.36 (s, 1H), 7.47 (d, 2H, J=7.8 Hz), 7.53 (s, 1H), 7.75 (s, 1H), 7.93 (d, 2H, J=7.8 Hz), 10.13 (s, 1H), 10.60 (s, 1H), 13.36 (s, 1H); LC-MS: 533.2 (MH+).
WORKUP
后处理
- concentrationIt is then concentrated
- custompurified by HPLC