Pyrrole-2-carboxaldehyde → 4-(4-methyl-piperazin-1-ylmethyl)-N-{3-[2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-5-ylamino]-phenyl}-benzamide

HRID 422029Notes

Reaction equation

HRID 422029 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[CH:34]=[CH:33][C:12]([C:13]([NH:15][C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([NH:22][C:23]4[CH:24]=[C:25]5[C:29](=[CH:30][CH:31]=4)[NH:28][C:27](=[O:32])[CH2:26]5)[CH:17]=3)=[O:14])=[CH:11][CH:10]=2)[CH2:4][CH2:3]1.[NH:35]1[CH:39]=[CH:38][CH:37]=[C:36]1[CH:40]=O>C(O)C.N1CCCCC1>[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([CH2:8][C:9]2[CH:10]=[CH:11][C:12]([C:13]([NH:15][C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([NH:22][C:23]4[CH:24]=[C:25]5[C:29](=[CH:30][CH:31]=4)[NH:28][C:27](=[O:32])[C:26]5=[CH:40][C:36]4[NH:35][CH:39]=[CH:38][CH:37]=4)[CH:17]=3)=[O:14])=[CH:33][CH:34]=2)[CH2:6][CH2:7]1

Participants

5

Reactant 2

HCID 13854Pyrrole-2-carboxaldehydeHCID 598043734-(4-methyl-piperazin-1-ylmethyl)-N-[3-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-phenyl]-benzamide

Product 1

HCID 666757034-(4-methyl-piperazin-1-ylmethyl)-N-{3-[2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-5-ylamino]-phenyl}-benzamide

Reagents, catalysts & solvents 2

HCID 8082PiperidineCatalystHCID 702EthanolSolvent

Procedure

To a solution of 4-(4-methyl-piperazin-1-ylmethyl)-N-[3-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-phenyl]-benzamide (23 mg, 0.05 mmol) in ethanol (2 ml) is added 1H-pyrrole-2-carbaldehyde (16 mg, 0.17 mmol) and 2 drops of piperidine. The reaction is refluxed for 12 hours and then concentrated. The desired compound after HPLC purification: 1H NMR (DMSO-d6) δ 2.44-2.52 (m, 2H), 2.79 (s, 3H), 2.98-3.10 (m, 2H), 3.18-3.22 (m, 2H), 3.38-3.42 (m, 2H), 3.77 (s, 2H), 6.32-6.36 (m, 1H), 6.61-6.69 (m, 111), 6.81-6.82 (m, 2H), 6.92 (dd, 1H, J=8.8 Hz, J2=1.6 Hz), 7.12-7.18, (m, 2H), 7.34 (s, 1H), 7.46 (dd, 2H, J=4.8 Hz, J2=1.6 Hz), 7.48 (s, 2H), 7.69 (s, 1H), 7.93 (d, 2H, J=8.0 Hz), 8.01 (s, 1H), 10.09 (s, 1H), 10.78 (s, 1H), 13.39 (s, 1H); LC-MS: 533.2 (MH+).

Workup

  1. temperatureThe reaction is refluxed for 12 hours
  2. concentrationconcentrated
  3. customThe desired compound after HPLC purification

Sources & evidence

ORD record
ord-2539ffb97df644c8ad5a6f4ea2bb224e
Source dataset
uspto-grants-2012_01
Patent number
US08101608B2

Reaction notes

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