反应详情

tert-Butyl 2-[4-(2,2-dimethylbutyl)-1H-imidazol-2-yl]-2-[4-(5-fluoropyridin-2-yl)benzyl]pyrrolidine-1-carboxylate (45 mg, 0.089 mmol) was dissolved in trifluoroacetic acid (1 mL). After stirring at ambient temperature overnight, the reaction mixture was concentrated in vacuo to afford the title compound. 1H NMR (500 MHz, CD3OD) δ 8.48 (d, J=2.5 Hz, 1 H), 8.28 (br s, 1 H), 7.83 (dd, J=8.7, 4.2 Hz, 1 H), 7.79 (d, J=8.0 Hz, 2 H), 7.64 (td, J=8.5, 3.0 Hz, 1 H), 6.97 (d, J=8.0 Hz, 2 H), 6.86 (s, 1 H), 3.45-3.39 (m, 3 H), 3.24-3.17 (m, 1 H), 2.52-2.41 (m, 1 H), 2.45 (s, 2 H), 2.33-2.25 (m, 1 H), 2.22-2.13 (m, 1 H), 1.91-1.82 (m, 1 H), 1.22 (q, J=15.0, 7.5 Hz, 2 H), 0.84 (t, J=7.5 Hz, 3 H), 0.81 (s, 6 H); (M+H) found: 407.

1. concentrationthe reaction mixture was concentrated in vacuo