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HRID426074

反应详情

EQUATION

反应方程式

HRID 426074 的结构方程式

REACTANTS

反应物

3
结构：CN(C(=O)OC(C)(C)C)[C@H](CN)C[C@H]1CCCOC1
HCID58011482

tert-Butyl {(2S)-1-amino-3-[(3R)-oxan-3-yl]propan-2-yl}methylcarbamate

C14H28N2O3

结构：CNCC[C@@H](OCCNC(=O)OC)c1cccc(Cl)c1
HCID66704449

未命名化合物

结构：CCCCOC(=O)N[C@H](CN)C[C@H]1CCCCOC1
HCID86642389

未命名化合物

PRODUCTS

生成物

1
结构：CN[C@H](CNC(=O)N(C)CC[C@@H](OCCNC(=O)OC)c1cccc(Cl)c1)C[C@H]1CCCOC1
HCID25133025

未命名化合物

PROCEDURE

实验过程

The following compounds were prepared following procedures analogous to those described in Example 21 using (R)-methyl 2-(1-(3-chlorophenyl)-3-(methylamino)propoxy)ethylcarbamate and ten-butyl (S)-1-amino-3-((R)-oxepan-3-yl)propan-2-ylcarbamate and tert-butyl (S)-1-amino-3-((R)-tetrahydro-2H-pyran-3-yl)propan-2-yl(methyl)carbamate in Step 1. LC-MS (3 min) tR=1.2 m/z=500. 1H NMR (CD3OD) d 7.35-7.23 (m, 4H), 4.28 (dd, J=8.4, 4.4 Hz, 1H), 3.86-3.81 (m, 2H), 3.62 (s, 3H), 3.54 (br d, J=14.4 Hz, 1H), 3.50-3.23 (m, 10H), 3.14 (dd, J=11.2, 9.6 Hz, 1H), 2.90 (s, 3H), 2.74 (s, 3H), 1.95-1.43 (m, 8H), 1.26 (m, 1H).

WORKUP

后处理

  1. customThe following compounds were prepared
  2. customLC-MS (3 min) tR=1.2 m/z=500