反应详情

温度

95 °C

In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), a mixture of 1-(2-bromo-pyridin-4-yl)-ethanone (1650 mg, 8.25 mmol) in ethylene glycol (8.8 mL) was treated with trimethylorthoformate (1.85 mL, 16.88 mmol) followed by LiBF4 (158 mg, 1.65 mmol). The reaction mixture was heated at 95° C. overnight. Sat. aq. Na2CO3 (20 mL) was added and the mixture was extracted with Et2O (2×30 mL). The org. extracts were dried over Na2SO4, filtered, and the solvent was removed under reduced pressure. Purification of the residue by FC (6:1 to 2:1 hept-EA) gave the title compound as a yellow oil. TLC:rf (1:1 hept-EA)=0.57. LC-MS-conditions 02: tR=0.88 min; [M+H]+=244.19.

1. extractionthe mixture was extracted with Et2O (2×30 mL)
2. dry with materialextracts were dried over Na2SO4
3. filtrationfiltered
4. customthe solvent was removed under reduced pressure
5. customPurification of the residue by FC (6:1 to 2:1 hept-EA)