反应详情

A mixture of 1-benzyl-4-(6-methoxy-2-methylquinolin-8-yl)piperazine (0.527 g, 1.52 mmol), 10% Pd/C (0.20 g), and ammonium formate (0.96 g, 15.2 mmol) in methanol (10 mL) were heated at reflux under N2 for 3 hours. TLC analysis (35% EtOAc/hexane) indicated only a trace of starting material remained. After cooling to room temperature, the reaction was filtered through celite, washing with excess methanol. The filtrate was concentrated, diluted with CH2Cl2 (50 mL), and washed with saturated aqueous NaHCO3. The aqueous layer was extracted with CH2Cl2 (2×50 mL). The combined organic layers were dried over anhydrous sodium sulfate, filtered, and concentrated in vacuo to afford 0.37 g (95%) of the title compound as a yellow oil, which was used in the subsequent reaction without purification.

1. temperaturewere heated
2. temperatureat reflux under N2 for 3 hours
3. filtrationthe reaction was filtered through celite
4. washwashing with excess methanol
5. concentrationThe filtrate was concentrated
6. additiondiluted with CH2Cl2 (50 mL)
7. washwashed with saturated aqueous NaHCO3
8. extractionThe aqueous layer was extracted with CH2Cl2 (2×50 mL)
9. dry with materialThe combined organic layers were dried over anhydrous sodium sulfate
10. filtrationfiltered
11. concentrationconcentrated in vacuo