反应详情

To (S)-3-tert-Butoxycarbonylamino-1-[4-({[2-(2,3-dihydrobenzofuran-5-yl)-1-methylethyl]ethylamino}methyl)piperidin-1-yl]-propan-1-one (0.76 grams, 1.60 mmol) was added 20% trifluroacetic acid (20 ml). The reaction mixture was stirred at room temperature for 4 hours. The mixture was concentrated under reduced pressure and the residue was partitioned between dichloromethane and 1N sodium hydroxide. The organic layer was washed with water, dried over potassium carbonate and concentrated to give (S)-3-amino-1-[4-({[2-(2,3-dihydrobenzofuran-5-yl)-1-methylethyl]ethylamino}methyl)piperidin-1-yl]-propan-1-one as an oil (0.59 grams, 99%), M+H 373.

1. concentrationThe mixture was concentrated under reduced pressure
2. customthe residue was partitioned between dichloromethane and 1N sodium hydroxide
3. washThe organic layer was washed with water
4. dry with materialdried over potassium carbonate
5. concentrationconcentrated