反应详情

1-[1-(1-methyl-4-piperidinyl)-4-piperidinyl]-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (92 mg, 0.190 mmol) was dissolved in 25 ml of hot ethyl acetate and maleic acid(66 mg, 0.571 mmol) in 5 ml of hot ethyl acetate was added. After 2 hours at room temperature, the solid was filtered and then dried to give 135 mg of 1-[1-(1-methyl-4-piperidinyl)-4-piperidinyl]-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, trimaleate salt. 1H NMR (DMSO) 1.87 (m, 2H), 2.22 (m, 4), 2.45 (m, 2H), 2.77 (s, 3H), 2.18 (m, 9H), 5.06 (m, 1H), 6.11 (s, 6H), 7.15(m, 5H), 7.45 (m, 2H), 7.67 (d, J=8.51 Hz, 2H), 8.27 (s, 1H); LC/MS (MH+32 484).

1. filtrationthe solid was filtered
2. customdried