HRID432136

反应详情

EQUATION

反应方程式

REACTANTS

反应物

$结构：O=C(O)/C=C\C(=O)O$

HCID444266

Maleic acid

C4H4O4

结构：CC(C)N1CCC(N2CCC(n3nc(-c4ccc(Oc5ccccc5)cc4)c4c(N)ncnc43)CC2)CC1

HCID22347030

未命名化合物

2 次

PRODUCTS

生成物

$结构：CC(C)N1CCC(N2CCC(n3nc(-c4ccc(Oc5ccccc5)cc4)c4c(N)ncnc43)CC2)CC1.O=C(O)/C=C\C(=O)O.O=C(O)/C=C\C(=O)O.O=C(O)/C=C\C(=O)O$

HCID131724236

未命名化合物

收率 92.4%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8857

Ethyl acetate

C4H8O2

2 次

PROCEDURE

实验过程

1-[1-(1-isopropyl-4-piperidinyl)-4-piperidinyl]-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (Intermediate F) (132 mg, 0.258 mmol) was dissolved in 30 ml of hot ethyl acetate and maleic acid(90 mg, 0.774 mmol) in 5 ml of hot ethyl acetate was added. After 2 hours at room temperature, the solid was filtered and then dried to give 205 mg of 1-[1-(1-isopropyl-4-piperidinyl)-4-piperidinyl]-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, trimaleate salt. 1H NMR (DMSO) 1.26 (d, J=6.34 Hz, 6H), 1.90 (m, 2H), 2.23(m,4H), 2.50 (m, 2H), 3.53 (bm, 9H), 5.08 (m, 1H), 7.16 (m, 5H), 7.44 (m, 2H), 7.67 (d, J=8.30 Hz, 2H), 8.28 (s, 1H); LC/MS (MH+32 512).

WORKUP

后处理

filtrationthe solid was filtered
customdried

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e591f6c3885c4ffc83892fd22dcc378e
来源数据集: uspto-grants-2003_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06660744B1
来源说明: uspto-grants-2003_12

反应 SMILES

[CH:1]([N:4]1[CH2:9][CH2:8][CH:7]([N:10]2[CH2:15][CH2:14][CH:13]([N:16]3[C:20]4=[N:21][CH:22]=[N:23][C:24]([NH2:25])=[C:19]4[C:18]([C:26]4[CH:31]=[CH:30][C:29]([O:32][C:33]5[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=5)=[CH:28][CH:27]=4)=[N:17]3)[CH2:12][CH2:11]2)[CH2:6][CH2:5]1)([CH3:3])[CH3:2].[C:39]([OH:46])(=[O:45])/[CH:40]=[CH:41]\[C:42]([OH:44])=[O:43]>C(OCC)(=O)C>[C:39]([OH:46])(=[O:45])/[CH:40]=[CH:41]\[C:42]([OH:44])=[O:43].[C:39]([OH:46])(=[O:45])/[CH:40]=[CH:41]\[C:42]([OH:44])=[O:43].[C:39]([OH:46])(=[O:45])/[CH:40]=[CH:41]\[C:42]([OH:44])=[O:43].[CH:1]([N:4]1[CH2:9][CH2:8][CH:7]([N:10]2[CH2:15][CH2:14][CH:13]([N:16]3[C:20]4=[N:21][CH:22]=[N:23][C:24]([NH2:25])=[C:19]4[C:18]([C:26]4[CH:27]=[CH:28][C:29]([O:32][C:33]5[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=5)=[CH:30][CH:31]=4)=[N:17]3)[CH2:12][CH2:11]2)[CH2:6][CH2:5]1)([CH3:3])[CH3:2]