HRID432139
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
PROCEDURE
实验过程
1-[1-(4-piperidyl)-4-piperidyl]-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (108 mg, 0.230 mmol) was dissolved in 25 ml of ethanol and maleic acid (80 mg, 0.690 mmol) in 5 ml of hot ethanol was added. After 2 hours at room temperature, the solid was filtered and dried to give 155 mg of 1-[1-(4-piperidyl)-4-piperidyl]-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, trimaleate salt. 1H NMR (DMSO) 1.80 (m, 2H), 2.42 (m, 4), 2.51 (m, 2H), 2.95 (m, 3H), 3.44 (bm, 7H), 5.06 (m, 1H), 6.10 (s, 6H), 7.15 (m, 5H), 7.45 (m, 2H), 7.67 (d, J=8.5 Hz, 2H), 8.27 (s, 1H); LC/MS (MH+32 484).
WORKUP
后处理
- filtrationthe solid was filtered
- customdried