反应详情

To a solution of 3,5-dimethyl-4-(4′-methoxyphenoxy)nitrobenzene (4.0 g) (J. Med. Chem., 38: 703 (1995)) in chloroform (150 ml) were added N-bromosuccinimide (2.6 g) and trifluoroacetic acid (1.1 ml), and the resulting mixture was heated under reflux for 90 min. Additional portions of N-bromosuccinimide (2.6 g) and trifluoroacetic acid (1.1 ml) were added, followed by further heating for 18 h. The reaction was washed with sodium bicarbonate, dried (Na2SO4) and concentrated to afford the title compound of Step A as an orange solid (5.0 g). MS (APCl+) Calc: 351; Found: 352 (M+1).

1. temperaturethe resulting mixture was heated
2. temperatureunder reflux for 90 min
3. temperatureby further heating for 18 h
4. washThe reaction was washed with sodium bicarbonate
5. dry with materialdried (Na2SO4)
6. concentrationconcentrated