反应详情

To 0.93 g of methyl [2-{2-chloro-5-[2,6-dioxo-4-(trifluoromethyl)-1,2,3,6-tetrahydropyrimidin-1-yl]-4-fluorophenoxy}phenoxy]acetate, were added 10 ml of N,N-dimethylformamide and 0.31 g of potassium carbonate, then, 0.58 g of methyl iodide was added to the reaction solution, and the mixture was stirred at room temperature for 2 hours. 50 ml of diluted hydrochloric acid was added to the reaction solution and extracted with ethyl acetate. The organic layer was washed with water and then saturated saline, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to obtain 0.82 g of methyl [2-{2-chloro-4-fluoro-5-[3-methyl-2,6-dioxo-4-(trifluoromethyl)-1,2,3,6-tetrahydropyrimidin-1-yl]phenoxy}phenoxy]acetate [Compound 3-11 of the present invention].

1. extractionextracted with ethyl acetate
2. washThe organic layer was washed with water
3. dry with materialsaturated saline, dried over anhydrous sodium sulfate
4. concentrationconcentrated under reduced pressure